Fonts in OSX
Manually cleaning up your System Font and Application Font folders
To achieve the clean up of your System and Application font folders it is necessary to remove all fonts that are not essential for the operation of OSX. You may not use these fonts in your day-to-day work but it is a good idea to save them.

1. Create a folder in
My Fonts and call it Fonts from System.

2. Create a new folder within the
Fonts from System folder and name it Library Fonts.

3. Move all the fonts from
/Library/Fonts to your Library Fonts folder.

4. Create a new folder within the
Fonts from System folder and name it User Fonts

5. Move all the fonts from
/Users/[name]/Library/Fonts to your User Fonts folder.

6. If you have a Classic System Folder (it will have an OS 9 icon and can be found at the root level of your main hard disk) and you want these fonts to be managed by your font manager in OSX then you should move these fonts. Once moved, these fonts will no longer be available to OS 9 applications.
Create a folder and call it
Classic Fonts within the Fonts from System folder. Move all the fonts in /System Folder/Fonts to your new folder except the following fonts

Charcoal
Chicago
Geneva
Monaco
These fonts are essential to the normal system operation.

7. You must be logged in as a user with Administrator rights to move
System Domain Fonts. Create a folder and name it System Fonts in the Fonts from System folder.
Select all the fonts in the
/System/Library/Fonts folder except the following essential system fonts:

AppleGothic.dfont
AquaKanaBold.otf
AquaKanaRegular.otf
Courier.dfont
Geneva.dfont
HelveLTMM
Helvetica LT MM
Hiragino Kaku Gothic Pro W3.otf
Hiragino Kaku Gothic Pro W6.otf
Hiragino Maru Gothic Pro W4.otf
Hiragino Mincho Gothic Pro W3.otf
Hiragino Mincho Gothic Pro W6.otf
Keyboard.dfont
LastResort.dfont
LucidaGrande.dfont
Osaka.dfont
OsakaMono.dfont
Times LT MM
TimesLTMM

Copy the selected fonts from the
/System/Library/Fonts folder to the System Fonts folder you created.
Press
Command-Delete to remove the selected files from the System Folder. At the prompt enter your Administrator password and click OK.

Adobe Application Fonts
If you have installed applications from Adobe (which is quite likely) font files will have been placed in a special location. You could leave the fonts here if you wish, but if you want to use them in other non-Adobe programs and/or are using a font managements program you can move them. To locate and move these files:

1. Create a folder and name it
Adobe Application Fonts within the Fonts from System folder.

2. Move all the fonts in
/Library/Application Support/Adobe/Fonts except the folder named Reqrd and the fonts in this folder.

A note about Helvetica
Helvetica is not an essential system font. However, some applications still require an active version of Helvetica to operate. As soon as you remove Helvetica from your system font folders, be sure to activate a version of Helvetica using your font manager. It doesn't matter which font format you use (PostScript, TrueType, OpenType, etc). For professional publishing and print I recommend using a PostScript version of Helvetica. (See Re-installing fonts and Installing new fonts)

>> Re-installing fonts